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Immunologic Response to ART by Age Among Treatment-Naive Patients in Sub-Saharan Africa
UMB Dataset

Alternate Titles(s): Immunologic Response to Antiretroviral Therapy by Age Among Treatment-Naive Patients in Sub-Saharan Africa

UID: 19

Author(s): Kristen A. Stafford*, Laurence S. Magder, Laura L. Hungerford, Jack M. Guralnik, Samer S. El-Kamary, Mona Baumgarten, Robert R. Redfield * Corresponding Author
Description
This study investigated the association of age with CD4+ cell counts of HIV patients receiving antiretroviral treatment (ART) over a 4 year period. Data were collected from 126,672 previously treatment-naïve patients in 4 Sub-Saharan African nations. The baseline CD4+ count was measured at onset of ART and at 6-month intervals thereafter. The predictor variable was the age at initiation of therapy with ages grouped in five 10-year ranges: 20-29, 30-39, 40-49, 50-59, and 60 and over. The following 8 baseline covariates were also noted: sex, WHO stage, functional status, active TB infection, active cryptococcal disease, active P. jiroveci pneumonia, other active opportunistic infections, and ART regimen. The resulting dataset includes 466,482 repeated CD4+ count measurements with demographic and other patient-related characteristics.
Timeframe
2004 - 2012
Geographic Coverage
Kenya
NIgeria
Tanzania
Uganda
Subject of Study
Subject Domain
Population Age
Adult (19 years to 64 years)
Senior (65 years to 79 years)
Elderly (80 years and over)
Subject Gender
Female
Male
Keywords
Access Instructions
Please contact Dr. Kristen Stafford
Associated Publications
Data Type
Software Used
SAS 9.4
Study Type
Observational
Dataset Format(s)
CSV
Grant Support
NIH K12 Career Development Award/NIH
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