Residents from 13 community-based nursing homes located in Maryland and Michigan participated in this study of MRSA transmission rates to healthcare personnel (HCP) during routine care activities. Upon enrollment, cultures were taken at the anterior nares and perianal skin. Of the 401 participants, 113 were MRSA colonized. A random sample of non-colonized residents were also included in the study. HCP gloves and gowns were swabbed after each interaction with participants and the activity type and duration recorded. This dataset includes resident characteristics (demographics, health status, etc.) type of care activity, and transmission rates.