UMB Data Catalog
A project of the Health Sciences and Human Services Library-
Plasmodium vivax Transcriptomes Reveal Stage-specific Chloroquine Response and Differential Regulation of Male and Female Gametocytes
UMB Dataset- Authors
- Adam KimJean PopoviciDidier MenardDavid Serre
- Description
Plasmodium vivax is the most widespread human malaria parasite. However, its biology is little understood for a number of reasons, not the least of which is the inability to continuously propagate it in vitro. Utilizing samples of whole blood taken from 26 Cambodian patients who were determined to be solely infected with the parasite, this research investigated three aspects of P. vivax activity: 1) the statistical contribution of the different developmental stages present in infection using gene expression deconvolution; 2) the regulation of expression of gametocyte genes, and 3) the effect of chloroquine on the P. vivax transcriptome. The primary dataset includes RNA-sequencing reads from the blood of the Cambodian patients as well as reads derived from dissected sporozoites from mosquitoes. Four supplementary data files provide additional details from the study.
- Subject
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Gene Expression ProfilingPlasmodium vivax
- Geographic Coverage
- International
- Access Rights
- Unrestricted access