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  • UMB Dataset

    Small molecules inhibitors of the heterogeneous ribonuclear protein A18 (hnRNP A18): a regulator of protein translation and an immune checkpoint

    Authors
    Eduardo Solano-Gonzalez
    Katherine M. Coburn
    Wenbo Yu
    Gerald M. Wilson
    6 more author(s)...
    Description

    Researchers utilized SILCS-based techniques to map the functional group requirements of hnRNP A18, aiming to create a pharmacophore for virtual screening. Data was obtained using the crystal structure of the hnRNP A18 RRM domain and various software tools. These simulations generated 3D functional group probability distributions of organic solutes, forming the basis for pharmacophore models. Virtual...

    Subject
    RNA-Binding Proteins / chemistry
    RNA-Binding Proteins/antagonists & inhibitors
    Access Rights
    Unrestricted access