The Health Outcomes and Measures of the Environment (HOME) Study, a prospective pregnancy and birth cohort in the greater Cincinnati OH metropolitan area, was established to determine whether early life environmental chemical exposures influence children’s health. Data include longitudinal and repeated measures of chemical exposures and child health beginning in the gestational age of 16.0 weeks with follow ups until 8 years of age. This includes 100+ environmental chemical exposures measured in women and children, as well as repeated measures of child neurodevelopment, anthropometry, respiratory and allergy outcomes, and injuries.