This dataset is the result of a multi-center, 7 year prospective investigation into the biopsychosocial, environmental, and genetic risk factors associated with the onset and persistence of temporomandibular disorders (TMD). The OPPERA project consisted of 4 observational studies: a prospective cohort study of first-onset TMD, a baseline case-control study of chronic TMD, a matched case-control study of incident TMD, and a prospective case-cohort study of the course of TMD. Over 3,000 volunteers between the ages of 18-44 participated in the research. The data collected includes sociodemographic, psychosocial, clinical, physiological, and genetic (including biological pathways of genetic variants).