This dataset represents a comparison of polypharmacy among youth with serious emotional and behavioral disorders enrolled in coordinated care services (CCS) versus those receiving traditional mental health services. Data were extracted from Medicaid administrative claims (demographic, diagnosis by ICD-9 code, procedure codes, and psychotropic medication), child welfare administrative records, and juvenile justice records. The final analytic sample included a total of 814 CCS youths and 993 in the traditional care cohort.