UMB Data Catalog
A project of the Health Sciences and Human Services Library-
Deep dissection of the antiviral immune profile of patients with COVID-19
UMB Dataset- Authors
- Djordje AtanackovicStephanie V. AvilaForat LutfiDiego de Miguel-Perez16 more author(s)...
- Description
This dataset collected 40 ml of heparinized blood from 20 COVID-19 patients who were admitted to the University of Maryland Medical Center between June and August of 2020. Plasma samples were collected at a median of 10 or 7 days, dependent on the patient's risk group. Samples were analyzed using full-length recombinant protein in an enzyme-linked immunosorbent assay (ELISA). Antibodies were screened against 9 different SARS-CoV-2 proteins. Responses were observed against the spike (S) proteins, the receptor-binding domain (RBD), and the nucleocapsid (N) protein which were of the IgG1 and IgG3 subtypes. Studies using this dataset aim to identify the most relevant component of the anti-SARS-CoV-2 humoral immune response and enable researchers to design more meaningful immunomonitoring methods for anti-COVID19 vaccines.
- Subject
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Antibodies, Neutralizing/immunologyAntibodies, Viral/immunologyCOVID-19/immunologyViral Proteins/immunology
- Geographic Coverage
- Baltimore (Md.)
- Timeframe
- 2020
- Access Rights
- Unrestricted access