UMB Data Catalog

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  • UMB Dataset

    Region-Specific Response of Astrocytes to Prion Infection

    Authors
    Natallia Makarava
    Jennifer Chen-Yu Chang
    Rajesh Kushwaha
    Ilia V. Baskakov
    Description

    Chronic neuroinflammation is a common pathological hallmark of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, ALS, and prion disorders. Both reactive microgliosis and astrogliosis have been identified as having a role in the neuroinflammatory process. Studies of prion diseases of animals and humans have demonstrated activation and proliferation of microglia at the very early subclinical...

    Subject
    Neurodegenerative Diseases
    Prion Diseases
    Access Rights
    Unrestricted access
  • UMB Dataset

    Tip60- and Sirtuin 2-Regulated MARCKS Acetylation and Phosphorylation Are Required for Diabetic Embryopathy

    Authors
    Penghua Yang
    Cheng Xu
    E. Albert Reece
    Xi Chen
    5 more author(s)...
    Description

    A high glucose level associated with maternal diabetes has been identified as a risk factor for fetal neural tube defects (NTD). The failure to successfully complete the complex neurulation process is possibly related to the loss of protection for cellular homeostasis resulting in organelle stress. Mitochondrial dysfunction and endoplasmic reticulum stress in the developing endothelium have been identified...

    Subject
    Neurulation
    Pregnancy in Diabetics
    Access Rights
    Unrestricted access