Description: Children with sickle cell disease (SCD) experience neurodevelopmental decline over time. They also tend to have short duration, poor quality sleep and elevated fatigue levels. This study measured sleep via actigraphy over one week and cognitive and behavioral measures in 19 children and adolescents with SCD. Aged 7-18 years, the majority of participants were referred for neurodevelopmental testing due to academic or behavioral difficulties. Data was collected from parent report, medical record, and included age, sex, race, SCD genotype, results of neuroimaging studies including brain magnetic resonance imaging (MRI) and transcranial Doppler (TCD) velocities, and current use of hydroxyl urea or chronic blood transfusion. Additionally, parents completed the Behavior Rating Inventory of Executive Function (BRIEF), participants completed the Wide Range Achievement Test (WRAT), and both completed the PedsQL Multidimensional Fatigue Scale.
Timeframe: 2013 - 2015

Subject of Study

Subject Domain

Population Age

Child (2 years to 12 years)

Adolescent (13 years to 18 years)

Subject Gender

Female

Male

Keywords

Restrictions: Unrestricted access
Instructions: Available via the Open Science Framework (OSF); Access via Open Science Framework (OSF)
https://doi.org/10.17605/OSF.IO/H6NAJ