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  • Nanomagnetic-Mediated Drug Delivery for the Treatment of Dental Disease
    UMB Dataset

    Authors
    Radi Masri
    Description

    This research tested the efficacy of utilizing nanoparticles, external magnetic forces, and dentinal tubules as conduits for delivering therapeutic agents to dental pulp. Moderate-size cavities were created in the dentin of rat mandibular molars and treated via the use of external magnetic forces to actively transport prednisolone-eluting magnetic nanoparticles to tooth pulp. Control groups included untreated teeth and teeth treated without magnetic pull. Expression of 4 cytokines were assessed at 2 weeks, 4 weeks, and 6 months. Additionally, the delivery system was investigated for use in actively guiding resin adhesives and the effect on shear bond strength on freshly extracted human molars. Dataset includes cytokine expression analysis and histological data.

    Subject
    Endodontics

  • Mutations in Diphosphoinositol-Pentakisphosphate Kinase PPIP5K2 are associated with hearing loss in human and mouse
    UMB Dataset

    Authors
    Saima Riazuddin
    Rizwan Yousaf
    Chunfang Gu
    Zubair M. Ahmed
    4 more author(s)...
    Description

    Genetically complex non-syndromic recessively inherited hearing loss (NSRHL) comprises approximately 75% of hereditary deafness. This study investigated NSRHL in two large consanguineous Pakistani families. Exome sequencing coupled with homozygosity mapping was used to identify a missense variant in PPIP5K2 gene associated with nonsyndromic, prelingual sensorineural deafness. Biochemical analysis was performed to compare wild type human PPIP5K2 with the variant. Additional research was conducted on mouse mutants to observe the effects on the outer hair cells and hearing thresholds. This dataset includes genetic, hearing function, gene expression, and histological data and images.

    Subject
    Hearing Loss
    Point Mutation
    Geographic Coverage
    International
    Access Rights
    Unrestricted access

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