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  • A 2-Year Clinical Evaluation of Fissure Sealants
    UMB Dataset

    Alternate Title(s)
    Evaluation of Resin Based and Glass Ionomer Based Sealants Placed With or Without Tooth Preparation
    Authors
    Vineet Dhar
    Haiyan Chen
    Description

    25 children ranging in age from 6 to 10 years participated in this bilateral split-mouth study evaluating two dental sealants for retention and secondary caries development. Data were collected comparing resin based and glass ionomer based sealants with and without tooth preparation at 6-month intervals over a 2 year period. Dataset includes demographic and clinical measures and sealant performance evaluation and comparison at 6, 12, 18 and 24 months.

    Subject
    Dental Materials
    Geographic Coverage
    India
    Access Rights
    Application Required
  • Immunologic Response to ART by Age Among Treatment-Naive Patients in Sub-Saharan Africa
    UMB Dataset

    Alternate Title(s)
    Immunologic Response to Antiretroviral Therapy by Age Among Treatment-Naive Patients in Sub-Saharan Africa
    Authors
    Kristen A. Stafford
    Laurence S. Magder
    Laura L. Hungerford
    Jack M. Guralnik
    3 more author(s)...
    Description

    This study investigated the association of age with CD4+ cell counts of HIV patients receiving antiretroviral treatment (ART) over a 4 year period. Data were collected from 126,672 previously treatment-naïve patients in 4 Sub-Saharan African nations. The baseline CD4+ count was measured at onset of ART and at 6-month intervals thereafter. The predictor variable was the age at initiation of therapy with ages grouped in five 10-year ranges: 20-29, 30-39, 40-49, 50-59, and 60 and over. The following 8 baseline covariates were also noted: sex, WHO stage, functional status, active TB infection, active cryptococcal disease, active P. jiroveci pneumonia, other active opportunistic infections, and ART regimen. The resulting dataset includes 466,482 repeated CD4+ count measurements with demographic and other patient-related characteristics.

    Subject
    HIV Infections
    Geographic Coverage
    Kenya
    Nigeria
    Tanzania
    Uganda
  • Factors Associated with Outcomes of Pre-ART HIV Care
    UMB Dataset

    Alternate Title(s)
    Factors Associated with Outcomes of Pre-Antiretroviral HIV Care
    Authors
    Kristen A. Stafford
    Lucy W. Nganga
    Tuhuma Tulli
    Karen G. Fleischman Foreit
    Description

    In 2015 the World Health Organization (WHO) eliminated CD4 restrictions for initiating antiretroviral therapy (ART) for people living with HIV (PLHIV) in developing countries. However, the success of therapy is also dependent upon additional health and demographic characteristics of HIV patients at the time they enroll in care. This study investigated pre-ART (time between enrollment and initiation of ART) factors associated with transition to therapy. Data was compiled from a review of 195,011 records of ART-naïve adults enrolled in HIV care and treatment facilities supported by AIDSRelief in Kenya and Tanzania. The outcome variable was transition out of pre-ART care by one of 4 mutually exclusive modes: started ART, died before ART initiation, lost to follow-up (LTFU), and transferred to another facility. The following baseline covariates were analyzed for their relevance to the mode of transition: sex, age at enrollment, CD4 count at enrollment, presence of tuberculosis at enrollment, presence of cryptococcal disease at enrollment, presence of other active opportunistic infections, and year of enrollment in care. The dataset includes demographic data and clinical measures.

    Subject
    HIV Infections
    Geographic Coverage
    Kenya
    Tanzania
  • Amish Complex Genetic Disease Database
    UMB Dataset

    Description

    The Amish Research Group of the University of Maryland School of Medicine has been studying the Old Order Amish population in Lancaster County, PA, since 1993. This database currently consists of health-related data on over 7,000 adults resulting from studies ranging from population and basic science to clinical and translational research. Areas of investigation include: Cardiovascular Risk, Diabetes, Bone Health, Blood Pressure, Vascular Imaging, Aging, Breast Tissue Density, Platelet Aggregation, Microbiome, Wellness, and Brain Imaging. Extensive genetic data (genotyping and sequencing) is also available.

    Subject
    Amish
    Ethnic Groups/genetics
    Genetics, Population
    Health Status Indicators
    Geographic Coverage
    Pennsylvania
    Access Rights
    Access granted on an individual basis dependent upon request and consent considerations
    Local Experts
    Alan R. Shuldiner
    Braxton C. Mitchell
  • Orofacial Pain: Prospective Evaluation and Risk Assessment (OPPERA)

    Alternate Title(s)
    OPPERA
    Description

    This dataset is the result of a multi-center, 7 year prospective investigation into the biopsychosocial, environmental, and genetic risk factors associated with the onset and persistence of temporomandibular disorders (TMD). The OPPERA project consisted of 4 observational studies: a prospective cohort study of first-onset TMD, a baseline case-control study of chronic TMD, a matched case-control study of incident TMD, and a prospective case-cohort study of the course of TMD. Over 3,000 volunteers between the ages of 18-44 participated in the research. The data collected includes sociodemographic, psychosocial, clinical, physiological, and genetic (including biological pathways of genetic variants).

    Subject
    Craniomandibular Disorders
    Facial Pain
    Risk Factors
    Geographic Coverage
    Florida
    Maryland
    New York (State)
    North Carolina
    Access Rights
    Submission of a Data Access Request via the dbGaP controlled access portal
    Local Experts
    Joel D. Greenspan
    Meg Johantgen
    Shijun Zhu
    Susan G. Dorsey
  • Comparative Measurement of PLMS Between Polysomnography and Actigraphy in Children with Sickle Cell Disease
    UMB Dataset

    Authors
    Valerie E. Rogers
    Paul R. Gallagher
    Carole L. Marcus
    Kwaku Ohene-Frempong
    2 more author(s)...
    Description

    Periodic limb movements in sleep (PLMS) are associated with sleep fragmentation and sympathetic nervous system activation, which in turn have been linked to cognitive and behavioral deficits in children and cardiovascular morbidity in both adults and children. Emerging evidence indicates that many children with sickle cell disease (SCD) have elevated PLMS. The specific aims of this prospective, repeated-measures, descriptive study were to assess the agreement between PLMS measurement by actigraphy and concurrent polysomnography (PSG), to test the feasibility of measuring PLMS by actigraphy at home, to evaluate PLMS variability over consecutive nights by actigraphy, and to provide preliminary data on objective and subjective correlates of PLMS. Twenty children with SCD and restless legs syndrome (RLS) symptoms or polysomnography-documented PLMS underwent concurrent attended polysomnography and ankle activity monitoring over one to two nights and home activity monitoring for three nights. Serum iron and ferritin were measured pre- and post-polysomnography. The datasets associated with this study include demographic data, SCD subtype, polysomnographic/activity monitor values, medical history, and clinical measures.

    Subject
    Anemia, Sickle Cell
    Sleep Wake Disorders
    Geographic Coverage
    Pennsylvania
    Access Rights
    Free to All
  • Sleep Disturbances in Neurobehaviorally Challenged Children with Sickle Cell Disease
    UMB Dataset

    Authors
    Valerie E. Rogers
    Eboni I. Lance
    Description

    Children with sickle cell disease (SCD) experience neurodevelopmental decline over time. They also tend to have short duration, poor quality sleep and elevated fatigue levels. This study measured sleep via actigraphy over one week and cognitive and behavioral measures in 19 children and adolescents with SCD. Aged 7-18 years, the majority of participants were referred for neurodevelopmental testing due to academic or behavioral difficulties. Data was collected from parent report, medical record, and included age, sex, race, SCD genotype, results of neuroimaging studies including brain magnetic resonance imaging (MRI) and transcranial Doppler (TCD) velocities, and current use of hydroxyl urea or chronic blood transfusion. Additionally, parents completed the Behavior Rating Inventory of Executive Function (BRIEF), participants completed the Wide Range Achievement Test (WRAT), and both completed the PedsQL Multidimensional Fatigue Scale.

    Subject
    Anemia, Sickle Cell
    Neurodevelopmental Disorders
    Sleep Wake Disorders
    Access Rights
    Free to All
  • Polysomnographic Characteristics of a Referred Sample of Children with Sickle Cell Disease
    UMB Dataset

    Authors
    Valerie E. Rogers
    Daniel S. Lewin
    Glenna B. Winnie
    Jeanne Geiger-Brown
    Description

    This was a retrospective medical record review of 55 consecutive children aged 2-18 years with sickle cell disease (SCD) (hemoglobin [Hb] SS and Hb SC genotypes) undergoing polysomnography for evaluation of sleep disordered breathing. Polysomnography values were compared between SCD genotypes, 4 age groups, and adenotonsillectomy status using descriptive and nonparametric statistics. Medical record data were collected for 12 months pre-polysomnography and 12 months post-polysomnography/adenotonsillectomy. This dataset includes demographic data, SCD type, polysomnographic values, and clinical measures.

    Subject
    Anemia, Sickle Cell
    Sleep Wake Disorders
    Access Rights
    Free to All
  • Biomarkers of Airway Inflammation and Asthma Control in Children with Comorbid Sleep-Disordered Breathing
    UMB Dataset

    Authors
    Valerie E. Rogers
    Mary E. Bollinger
    Mohan E. Tulapurkar
    Shijun Zhu
    3 more author(s)...
    Description

    A bi‐directional relationship exists between asthma and obstructive sleep apnea (OSA) in which presence of one is associated with increased prevalence and severity of the other. This study was undertaken to determine if OSA accounted for differences in airway and systemic inflammation in asthmatic children and if inflammation was associated with asthma control. 27 non-obese children aged 4-12 years with persistent asthma, with or without OSA, were recruited for the research. Asthma control was measured with the Childhood Asthma Control Test. Participants underwent polysomnography and blood sampling, and those with OSA also underwent clinically indicated adenotonsillectomy. Tonsils and sera were analyzed for 11 cytokines. The dataset includes demographic data, health history, spirometry/polysomnographic measures, and immunoassay values.

    Subject
    Asthma
    Inflammation
    Sleep Wake Disorders
    Access Rights
    Free to All
  • Circadian Rest-Activity Rhythms in Children with Leukemia on Dexamethasone
    UMB Dataset

    Authors
    Valerie E. Rogers
    Belinda Mandrell
    Description

    This study measured circadian activity rhythms (CAR) and fatigue in children and adolescents with acute lymphoblastic leukemia on maintenance chemotherapy during the 5 days prior to a pulse of dexamethasone and the 5 days after the start of dexamethasone. CAR was measured via an actigraph worn continuously for 10 days. Fatigue was measured at 4 time points. The fatigue measures used for this study were Fatigue Scale-Child, Fatigue Scale-Adolescent and Fatigue Scale-Parent. The aims of this descriptive study were to compare CAR during the periods before and during dexamethasone therapy, and to explore the hypothesis that less robust CAR was associated with greater fatigue.

    Subject
    Circadian Rhythm
    Dexamethasone
    Leukemia
    Geographic Coverage
    Canada
    United States
    Access Rights
    Free to All