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  • Kinetics of SARS-CoV-2 antibody responses preCOVID-19 and post-COVID-19 convalescent plasma transfusion in patients with severe respiratory failure: an observational case–control study
    UMB Dataset

    Authors
    Magali J. Fontaine
    Matthew N. Klein
    Elizabeth Wenqian Wang
    Paul Zimand
    8 more author(s)...
    Description

    This observational retrospective control study investigated the development of the humoral immune response to SARS-CoV-2 in convalescent plasma (CCP) recipients (n=34) and compared it to the humoral response in a group of patients not treated with CCP (n=68). Additionally, a separate comparison of clinical outcomes was performed between CCP recipients and a matched control group of untreated patients (n=34). Patients considered for enrollment in the study presented with severe COVID-19 and were hospitalized in the intensive care units (ICU) of 3 Maryland hospitals. Participants received a single unit of ABO compatible CCP of approximately 250mL. Blood samples for SARS-CoV-2 antibody titre measurements were collected immediately pre-transfusion (day 0) and on days 3, 7 and 14 post-transfusion. Non-transfused patients were used for comparison of antibody titres. Sample draws from this cohort ranged from 0 to 48 days after the onset of symptoms, which varied in severity. Non-transfused patients used for the clinical outcome analysis were matched to CCP recipients based on sex, age, and on three levels of respiratory support requirement (non-ventilated, mechanically ventilated and ventilated with extracorporeal membrane oxygenation (ECMO)) and were admitted in the same hospital. This dataset includes clinical variables from all transfused and non-transfused participants including: symptoms at presentation, level of respiratory support (mechanical ventilation/ECMO status), comorbidities, other SARS-CoV-2 directed therapies, 30-days in-hospital mortality, number of days on mechanical ventilation, number of days on ECMO support, ICU length of stay (LOS) and hospital LOS. Clinical improvement was assessed primarily on survival at 30 days. Secondary outcomes included the number of days on ventilatory and/or ECMO respiratory support, LOS in the hospital and LOS in the ICU.

    Subject
    COVID-19
    Immunization, Passive
    Geographic Coverage
    Maryland
    Timeframe
    2020
    Access Rights
    Approval required

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