UMB Data Catalog

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Results Found: 2
  • UMB Dataset

    Single-Nucleus RNA-Seq Reveals Dysregulation of Striatal Cell Identity Due to Huntington’s Disease Mutations

    Authors
    Sonia Malaiya
    Marcia Cortes-Gutierrez
    Brian R. Herb
    Sydney R. Coffey
    5 more author(s)...
    Description

    The involvement of specific medium spiny neuro (MSN) subtype and of other striatal cell types remains poorly understood. To gain insight into cell type-specific disease processes, researchers studied the nuclear transcriptomes of 4524 cells from the striatum of a genetically precise knock-in mouse model of the Huntington's Disease (HD) mutation, HttQ175/1. Three 14-month-old and one 15-month-old male...

    Subject
    Sequence Analysis, RNA
    Timeframe
    2020
    Access Rights
    Unrestricted access
  • UMB Dataset

    Transcriptomic comparisons of macroscopically normal-appearing and scarred lung tissues in idiopathic pulmonary fibrosis

    Authors
    Sergei P. Atamas
    Description

    Idiopathic pulmonary fibrosis (IPF) produces scarring in the peripheral and basilar regions of the lung with macroscopically normal-appearing tissue in the central and apical areas. This study involved comparing transcriptomic profiles of the latter with transcriptomes of scarred IPF and healthy control lung tissues. The primary goal of the research was to elucidate the pathobiology of the disease...

    Subject
    Gene Expression Profiling
    Sequence Analysis
    Access Rights
    Unrestricted access