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  • UMB Dataset

    Nanomagnetic-Mediated Drug Delivery for the Treatment of Dental Disease

    Authors
    Radi Masri
    Description

    This research tested the efficacy of utilizing nanoparticles, external magnetic forces, and dentinal tubules as conduits for delivering therapeutic agents to dental pulp. Moderate-size cavities were created in the dentin of rat mandibular molars and treated via the use of external magnetic forces to actively transport prednisolone-eluting magnetic nanoparticles to tooth pulp. Control groups included...

    Subject
    Endodontics
  • UMB Dataset

    Mutations in Diphosphoinositol-Pentakisphosphate Kinase PPIP5K2 are associated with hearing loss in human and mouse

    Authors
    Saima Riazuddin
    Rizwan Yousaf
    Chunfang Gu
    Zubair M. Ahmed
    4 more author(s)...
    Description

    Genetically complex non-syndromic recessively inherited hearing loss (NSRHL) comprises approximately 75% of hereditary deafness. This study investigated NSRHL in two large consanguineous Pakistani families. Exome sequencing coupled with homozygosity mapping was used to identify a missense variant in PPIP5K2 gene associated with nonsyndromic, prelingual sensorineural deafness. Biochemical analysis was...

    Subject
    Hearing Loss
    Point Mutation
    Access Rights
    Unrestricted access