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Orofacial Pain: Prospective Evaluation and Risk Assessment (OPPERA)

Alternate Titles(s): OPPERA

UID: 62

This dataset is the result of a multi-center, 7 year prospective investigation into the biopsychosocial, environmental, and genetic risk factors associated with the onset and persistence of temporomandibular disorders (TMD). The OPPERA project consisted of 4 observational studies: a prospective cohort study of first-onset TMD, a baseline case-control study of chronic TMD, a matched case-control study of incident TMD, and a prospective case-cohort study of the course of TMD. Over 3,000 volunteers between the ages of 18-44 participated in the research. The data collected includes sociodemographic, psychosocial, clinical, physiological, and genetic (including biological pathways of genetic variants).
2006 - 2012
Geographic Coverage
Baltimore (Md.)
Buffalo (N.Y.)
Chapel Hill (N.C.)
Gainesville (Fla.)
Local Experts
Subject of Study
Subject Domain
Population Age
Adult (19 years to 64 years)
Subject Gender
Access Restrictions
Approval required
Registration required
Access Instructions
Available via the NCBI database of Genotypes and Phenotypes with submission of a Data Access Request.
Associated Publications
Data Type
Study Type