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Antidepressant treatment with fluoxetine during pregnancy and lactation modulates the gut microbiome and metabolome in a rat model relevant to depression
UMB Dataset

UID: 106

Author(s): Anouschka S. Ramsteijn, Eldin Jašarević, Danielle J. Houwing, Tracy L. Bale, Jocelien D.A. Olivier
Data and figures are provided on the effects of fluoxetine, a selective serotin reuptake inhibitor (SSRI) antidepressant, on the gut microbiome and metabolome in a rat model to better understand the effect of this drug on women during gestation and lactation. Throughout pregnancy and lactation, female rats received the SSRI fluoxetine or vehicle. High resolution 16S ribosomal RNA marker gene sequencing and targeted metabolic analysis were used to assess the fecal microbiome and metabolic availability, respectively.
Geographic Coverage
Groningen (Netherlands)
Subject of Study
Subject Domain
Access via European Nucleotide Archive (ENA)

Accession #: PRJEB30296 (ERP112729)

Access Restrictions
Unrestricted access
Access Instructions
The sequencing dataset supporting the conclusions of this article is freely available in the European Nucleotide Archive. Other downloadable data is within the article.
Associated Publications
Data Type
Software Used
Kyoto Encyclopedia of Genes and Genomes (KEGG)
Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt)
Random Forests implemented in R version 3.4.1
Study Type
Empirical Research
Dataset Format(s)
FTP, Galaxy
Data Collection Instruments
PSP® Spin Stool DNA Kit
mothur v. 1.39
QIIME version 1.9.1
Ribosomal Database Project (RDP) classifier v 2.2
Shannon Diversity Index
Grant Support
660152-DEPREG/European Union’s Horizon 2020 research and innovation program
25206/NARSAD young investigator grant
Fulbright/Fulbright Center The Netherlands
P50-MH099910, MH 104184, MH 091258, MH 087597, MH 073030, and MH 108286/National Institutes of Mental Health
Other Resources
Supplementary Material

accessible from the article via zip file